St James' history is tied up with the pioneers and founders of the city of Melbourne - names like Russell, Lonsdale, Bourke and La Trobe; alongside church leaders like Bishop Perry, his wife Frances (famous for founding the women's hospital), and Dean Hussey Burgh Macartney. In the twentieth century it was the home to a social welfare mission known as the Mission of St James and St John, which has since merged into Anglicare Victoria. More recently St James' was the host of a vibrant new Anglican church plant in a pub in the Docklands, now known as City on a Hill and meeting in a cinema. Over the past few years the Old Cathedral itself has been reviving as a home for those who love both the beauty of traditional Anglican worship and seek thoughtful and orthodox biblical teaching, attracting people of all ages including many young families.